Endocrine Abstracts

Background: Nonclassic congenital adrenal hyperplasia (NC-CAH) caused by mutations in CYP21B gene is an inherited disorder with various clinical forms in relation to the 21-hydroxylase (21OH) activity. Classic forms are recognized early during neonatal period as salt-wasting crisis or genital ambiguity, while non-classic form presents later with wide hyperandrogenic spectrum. Genetic testing has proved to be the definitive diagnostic method.Aim: To obser...

PTTG is tumourigenic in vivo and transactivates fibroblast growth factor-2 (FGF-2). We have previously identified expression of PTTG and FGF-2 as potential prognostic indicators for differentiated thyroid cancer. Critical to PTTG function is a double PXXP motif, forming a putative SH3-interacting domain. We employed cDNA array approaches to identify further genes regulated via this region. MCF12A cells were transiently transfected with vector-only (VO) control, wild-type (WT)-...

Methods: The diagnosis of Cushing’s Syndrome (CS) was made as per the prevalent endocrine society guidelines. CS patients with serum ACTH>15 pg/ml were considered as ACTH-dependent CS. Baseline ACTH (both inferior petrosal sinuses and peripheral) values were obtained, and since 2014, stimulated ACTH values (5 and 10 minutes post one unit iv vasopressin) were obtained as standard protocol. Prolactin corrected ACTH ratios were additionally being calculated since 2016. The h...

Background: Radioiodine(RAI) has been used to treat hyperthyroidism for more than seven decades. Effects of RAI treatment on thyroid function tests(TFT), risk of hypothyroidism, gland and autonomous nodule volumes and on ultrasonographic features in toxic adenoma (TA) and toxic multinodular goitre TMNG patients, have been previously studied by ourselves and other. However, studies evaluating ultrasonographic changes in thyroid and toxic nodule volumes usually have a follow-up ...

Background: Iodine deficiency and excess are well-recognized risk factors for thyroid dysfunction. This systematic reveiw and meta-analysis was designed, for the first time, to explore whether maternal iodine status or supplementation is associated with postpartum thyroid function.Methods: Electronic databases, including the MEDLINE/PubMed, Web of Science, Embase, and Scopus were searched between January 1923 and December 2021 to identify relevant studie...

Background and aims: We aimed to establish the frequency of vitamin D deficiency and analyse its association with gestational diabetes (GDM).Material and methods: In this descriptive, case control and cross sectional study, pregnant women were screened at 24–28 weeks of pregnancy using a 75 g, 2 h oral glucose tolerance test. Fourthy-six GDM diagnosed (case, group 1) and 43 healthy pregnants (control, group 2) were recruited. Plasma 25-hydroxyvitami...

Higher serum TSH has been recently postulated as a predictor of thyroid malignancy in nodular thyroid disease. In addition, some reports have demonstrated its association with more advanced stages of differentiated thyroid cancer (DTC).Material and methods: We collected retrospectively preoperative serum TSH from patients who underwent total thyroidectomy in the period 2005–2011 in a single tertiary center. We recorded demographic data, nodule numbe...

It is clear that effective control of blood glucose, hypertension and dyslipidemia, may prevent development of vascular complications in type 2 diabetes (T2DM).The aim of the present work was to reveal correlation between glycemia levels and mortality rate in T2DM patients (pts) with prior myocardial infarction (PMI).Materials: Totally, 131 T2DM pts with PMI were studied (mean age – 57.2±3.1 yrs; diabetes duration – ...

Background: It is generally believed that glycemic targets in diabetic pregnancies should mimic those found in normal pregnancies.Aim: The aim of the present work was to reveal how glycemia indices in pregnant patients with type 1 diabetes mellitus (T1DM), their infants’ birth weight (IBW).Methods: Totally, 128 pregnant women with T1DM were enrolled in the study (mean age – 26±7 yrs; diabetes duration – 10.2&#17...

Obesity-mediated diabetes is associated with insulin resistance/hyperinsulinaemia and chronic sub-clinical inflammation. Recent studies have highlighted fatty liver(steatosis) as a risk factor for diabetes. Fatty liver disease (FLD) progresses through fatty liver, necro-inflammation (non-alcoholic steatohepatitis, NASH) and fatwith fibrosis. In addition, hepatic steatosis per se can lead to hepatic insulin resistance/hyperin...